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OBJECTIVE To clarify the characteristic magnetic resonance imaging (MRI) findings in patients with spinocerebellar ataxia 6 (SCA6) diagnosed by genetic analysis. PATIENTS AND METHODS Using MRI, we examined 10 patients genetically diagnosed as having SCA6 and 40 control subjects. RESULTS The mean (+/-SD) CAG repeat length in 10 patients with SCA6 was(More)
Parkinson's disease (PD) is a movement disorder and tends to occur in elderly people, who sometimes develop age-related osteoporosis. Pathological bone changes seem to affect the outcome and prognosis of PD. We studied the relationship between bone changes and PD. Bone examination was conducted by multiple scanning X-ray photodensitometry in 70 patients(More)
OBJECTIVES To clarify the autonomic dysfunction in idiopathic Parkinson's disease (PD) and vascular parkinsonism (VP), we investigated the relationship between blood pressure (BP) and pulse rate (PR), the standing test, and the coefficient of variation in the R-R interval (CV[R-R]). MATERIALS AND METHODS BP and PR were determined automatically every 30(More)
Pathological bone changes affect locomotor activity and may influence the outcome and prognosis of Parkinson's disease (PD). In this study, we determined the relationship between bone changes and PD. Bone study was performed by multiple scanning x-ray photodensitometry (MD/MS) in 64 patients with PD and 42 age-matched controls. We then compared the results(More)
QTc intervals were measured using an electrocardiogram and other autonomic function tests, in 66 neuropathy patients with non-insulin-dependent diabetes mellitus (59.0±12.5 years; mean ± SD). The change in R-R interval did not influence the QTc interval, as calculated by the equation: QTc =QT+(1000-R-R)/7 (ms), compared with the conventional Bazett's(More)
Anticholinergic antiparkinsonian drugs have been widely used for the treatment of extrapyramidal disorders for a long time although their pharmacological characterization has been unclear. We studied the rank of potency of the effects of anticholinergic antiparkinsonian drugs to binding of 3H-QNB and 3H-PZ and calculated the affinity of each drug to the M1(More)
We identified a missense mutation of the Cu/Zn superoxide dismutase (SOD) gene (Leu126Ser) in a Japanese family with ALS that included a patient with the homozygous mutation. The content of the Cu/Zn SOD polypeptide in erythrocytes was markedly reduced in the case with the homozygous mutation compared to those with the heterozygous mutation. We speculated(More)
OBJECTIVES To clarify the autonomic dysfunctions in amyotrophic lateral sclerosis (ALS) patients, we investigated the relationship between blood pressure (BP) and pulse rate (PR), QTc interval, and coefficient of variation in the R-R interval (CVR-R) in ALS patients. MATERIALS AND METHODS BP and PR were determined automatically every 30 min for 24 h in 6(More)
Sudden death has been reported in Parkinson's disease (PD), but the cause of death has not been fully clarified. A prolonged QT interval on the electrocardiogram (ECG) of patients without cardiac dysfunction is an independent risk factor for sudden death regardless of etiology. QT prolongation is believed to be related to cardiac autonomic dysfunction. We(More)