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Possible alterations in mesenteric vascular reactivity to norepinephrine, angiotensin II, and arginine vasopressin and its relationship to prostaglandins in dexamethasone-induced hypertension in rats were investigated. The animals were treated with dexamethasone or its vehicle (sesame oil) for 1 day (1.8 mg/kg) and for 14 days (1.8 mg/kg/wk). The superior(More)
The effects of elastase on collagen biosynthesis and deposition in the aorta, heart and liver were investigated in spontaneously hypertensive rats (SHR). Prolyl hydroxylase activity (EC 1.14. 11.2; proline, 2-oxoglutarate dioxygenase) was significantly increased in the aorta of SHR compared with that of control. When elastase (10 mg/kg, i.p.) was given(More)
Our previous finding that dexamethasone-induced hypertension in rats is associated with enhanced reactivity of mesenteric arteries to arginine vasopressin but not to angiotensin II (Ang II) or norepinephrine has led us to postulate that vasopressin contributes to the development or maintenance of glucocorticoid-induced hypertension. To test this view, we(More)
The effects of hydergine on the secretion of pancreatic juice in the dog were investigated in preparations of the isolated, blood-perfused pancreas, and compared with those of secretin and dopamine. Hydergine (30-300 micrograms) injected intra-arterially caused dose-dependent increases in the secretion of pancreatic juice after a delay of a few min. The(More)
We examined the effects of plasma pH and plasma HCO-3 concentration on pancreatic HCO-3 secretion in resting state and in stimulated state by secretin, pancreozymin or dopamine, using the isolated blood-perfused dog pancreas. Secretin- or pancreozymin-induced HCO-3 secretion was sensitive to changes in both plasma pH and HCO-3 concentration. On the other(More)
The effects of nitroglycerin on the secretion of pancreatic juice and on the intracellular levels of cyclic nucleotides were investigated in preparations of the isolated, blood-perfused dog pancreas. Nitroglycerin (10-30 micrograms) injected intra-arterially caused a dose-dependent increase in the secretion of pancreatic juice within 30 sec. The(More)
The difference in the basal activities of NAD+-dependent aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) was investigated in the liver of age-matched spontaneously hypertensive (SH) and normotensive Wistar Kyoto (WK) rats. A significant difference between the SH and WK rats in the basal ALDH activity, ADH activity and the protein content of(More)
The effect of im administration of 500 micrograms TRH on serum amylase activity was studied in 34 normal women, 6 women with primary hypothyroidism, 1 woman with anorexia nervosa, 6 women with hyperthyroidism due to Graves' disease, and 5 women with renal failure on chronic hemodialysis. Serum amylase activity decreased significantly in 31 of 34 normal(More)
The effects of secretin, cholecystokinin, dopamine, histamine and acetylcholine on the secretion of pancreatic juice were investigated in the monkey and the dog. In the resting state, bicarbonate concentration and the volume of pancreatic juice in the monkey were greater than those in the dog. However, the protein concentration of pancreatic juice in the(More)