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The membrane of tissue-cultured chick pectoral muscle contains an ionic channel which is activated by membrane tension. With 150 mM-external K+ and 150 mM-internal Na+, the channel has a conductance of 70 pS and a reversal potential of +30 mV. With 150 mM-external Na+ and 150 mM-internal K+ (normal gradient) the channel has a conductance of 35 pS and a(More)
The membrane of tissue-cultured chick pectoral muscle contains an ionic channel which is activated by membrane stretch. Nicotinic channels and Ca2+-activated K+ channels are not affected by stretch. In 150 mM-external K+ and 150 mM-internal Na+ the channel has a conductance of 70 pS, linear current-voltage relationship between -50 and -140 mV and a reversal(More)
Differentiated murine neuroblastoma cells (NIE-115) have receptors for 5-hydroxytryptamine (5-HT), the activation of which either depolarizes or hyperpolarizes these cells with associated increases in input conductance. Ionophoresis of 5-HT on to NIE-115 cells elicits brief depolarization, but the 5-HT receptors rapidly desensitize during repeated(More)
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