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The purpose of this review is to outline recent developments in contrast agents for magnetic resonance angiography (MRA) and to give some idea of what the future might hold. Up to now, non-binding gadolinium (Gd) chelates have been the agents used for MRA. Modified paramagnetic Gd-based agents with varying degrees of protein interaction have been developed,(More)
RATIONALE AND OBJECTIVES To assess the vascular contrasting properties of a new MR contrast agent (gadobenate dimeglumine [Gd-BOPTA]), which presents higher relaxivity because of reversible, weak protein interaction, and, to compare these properties with a standard gadolinium agent. MATERIALS AND METHODS Two phase I trials compared intraindividually: (A)(More)
QUESTION The availability of new MR contrast agents having either a protein binding effect or higher concentration leads to the question if they differ from standard compounds in their vascular contrasting properties. METHODS By intraindividual comparison five volunteers were examined (1.5 T MR system) with a multi-phasic MRA of the abdomen each receiving(More)
BACKGROUND AND PURPOSE The detection of time-related maturational changes of the olfactory bulb (OB) on MR imaging may help early identification of patients with abnormal OB development and anatomic-based odor-cueing anomalies. MATERIALS AND METHODS Two separate reviewers retrospectively analyzed coronal T2-weighted spin-echo MR images of the frontobasal(More)
Activation of the cerebral cortex during motor task performance can be visualised with functional MRI. A modified FLASH sequence (TR/TE/alpha 100/60/40 degrees, first order flow rephased, fat suppression, reduced bandwidth 28 Hz/pixel, 120 repetitions, three cycles of rest and finger movement for each hand) on a standard 1.5 T clinical imager was used to(More)
Multiphase contrast-enhanced 3D MR angiography (MRA) data sets allow the separate visualization of the arterial and venous pulmonary vasculature. However, due to short arterial-to-venous bolus transit times in the lung, the generation of pure venograms without arterial overlay is difficult. To suppress arterial signal in venograms, early arterial phase data(More)
The purpose of this study was to demonstrate selective visualization of pulmonary arteries and veins with high spatial resolution for improved detection of vascular pathologies. Time-resolved pulmonary three-dimensional gadolinium-enhanced magnetic resonance angiograms (3D-Gd-MRA) were acquired with an ultrashort 3D fast low-angle shot (FLASH) sequence(More)
Fragestellung: Darstellung neuer diagnostischer Möglichkeiten im Bereich der Niere mittels schneller Magnetresonanz (MR)- Bildgebung. Methodik: Vorgestellt wird ein kombiniertes morphologisches und funktionelles Untersuchungskonzept bestehend aus schneller morphologischer Bildgebung, multiphasischer 3D-Gadolinium-MR-Angiographie, MR-Urographie und(More)
PURPOSE To review important aspects of study design in clinical radiology and to introduce the reader to the requirements of Good Clinical Practice (GCP). METHODS The European guidelines for GCP, the Declaration of Helsinki, the differentiation into study phases and the authors' own experience in open and sponsored clinical trials are the basis of this(More)
Magnetic resonance angiography is undergoing rapid development as a non-invasive technique to reliably assess renal artery stenosis. Invasive X-ray angiography is currently the gold standard imaging technique and gives excellent spatial resolution. However, its disadvantages include a necessary exposure to radiation and the need for iodinated contrast(More)