F. F. Roberts

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We have carried out an extensive pharmacological characterization of muscarinic binding sites in rabbit lung and chicken heart in parallel with M1, M2, and M3 sites, [3H]Pirenzepine, a selective antagonist at M1 receptors, bound saturably and reversibly to membranes from chicken heart and rabbit lung. These binding sites were not M1 receptors, however,(More)
A novel, nonlinear, phase space based method to quickly and accurately identify life-threatening arrhythmias is proposed. The accuracy of the proposed method in identifying sinus rhythm (SR), monomorphic ventricular tachycardia (MVT), polymorphic VT (PVT), and ventricular fibrillation (VF) for signals of at least 0.5s duration was determined for six(More)
1. The potency of a series of selective muscarinic antagonists has been measured on two functional isolated tissue preparations (rat ileum and atria) and these compared with their potency on a range of binding preparations in order to determine whether the subtypes of M2 receptor measured functionally are the same as those measured in binding studies. 2. On(More)
A preliminary study in the use of frequency sub-bands with reconstructed phase spaces (RPS) to distinguish between normal and abnormal atrial activity in an attempt to separate the atrial activation components from the ventricular activation components is presented. Two-second ECG Holter recordings of sinus rhythm (SR), atrial flutter (AFL), atrial(More)
We present the case of a 73-year-old woman who presented with clinical features of Cushing's syndrome, confirmed biochemically with elevated levels of cortisol and adrenocorticotrophic hormone (ACTH). Petrosal venous sampling showed no ACTH gradient and MRI of pituitary was normal, suggesting ectopic ACTH production. In the course of further investigations,(More)
BACKGROUND The efficacy of a novel anesthetic gel (lidocaine 25 mg/g plus prilocaine 25 mg/g in thermosetting agents) for non-invasive periodontal pocket anesthesia was evaluated. METHODS One hundred twenty-two (122) patients in 8 centers with moderate to severe periodontitis requiring scaling and root planing (SRP) were enrolled in this multicenter,(More)
Phlegmasia cerulea dolens (PCD) is the term describing the painful venous congestion that results from near-total venous occlusion of a limb. It is unusual in the lower extremity but is decidedly rare in the upper extremity with only a handful of cases reported in the literature. PCD of the upper extremity usually occurs in patients with significant(More)
A method is described for obtaining a highly active proteolytic enzyme from aMicrosporum species. This protease was purified (200-fold) from a cell-free culture medium by concentration with Carbowax, ammonium sulfate fractionation, charcoal and Celite filtration, calcium phosphate gel treatment, and column chromatography. The pH and temperature optima are(More)