F. F. Rakhmatullina

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Nitroglycerine in doses of 0.4–1.0 mg/kg decreased the heart rate in rats, which was associated with inhibition of adrenergic influences realized via β-adrenoceptors. The negative chronotropic effect of sodium nitroprusside in a dose of 1 mg/kg was more significant compared to that of nitroglycerine (by 2–3 times). It was associated with inhibition of(More)
Experimental myocardial infarction (coronary ligation without drug infusion) reduced heart rate, stroke volume, cardiac output, and blood pressure. Under conditions of blocked NO synthesis, experimental myocardial infarction was accompanied by a transient increase in heart rate, stroke volume, cardiac output, and blood pressure, followed by their decrease(More)
The effect of nitroglycerin in increasing doses (0.2-1.0 mg/kg) and sodium nitroprusside (1 mg/kg) on the heart rate, P-Q interval of ECG, and blood pressure was studied on 53 albino rats. NO donors nitroglycerin and sodium nitroprusside directly affected vascular endothelium (the maximum decrease in blood pressure was 28.5 and 57.0%, respectively) and(More)
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