F. DuBois Bowman

Learn More
Applications of functional magnetic resonance imaging (fMRI) have provided novel insights into the neuropathophysiology of major psychiatric, neurological, and substance abuse disorders and their treatments. Modern activation studies often compare localized task-induced changes in brain activity between experimental groups. Complementary approaches consider(More)
Recent work regarding the analysis of brain imaging data has focused on examining functional and effective connectivity of the brain. We develop a novel descriptive and inferential method to analyze the connectivity of the human brain using functional MRI (fMRI). We assess the relationship between pairs of distinct brain regions by comparing expected joint(More)
Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass. These changes might improve physical performance and strength; however, it has not been established whether T therapy improves functional outcome in older men. Moreover, concerns exist about the impact of T therapy on the prostate in older men. The(More)
UNLABELLED Conventional imaging techniques have serious limitations in the detection, staging, and restaging of prostate carcinoma. Anti-1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid (anti-(18)F-FACBC)is a synthetic l-leucine analog that has excellent in vitro uptake within the DU-145 prostate carcinoma cell line and orthotopically implanted prostate(More)
This study attempted to define further the neural processing events underlying social anxiety in patients with social anxiety disorder (SAD) and their response to pharmacotherapy. Social anxiety-related changes in regional cerebral blood flow were defined by [15O]H2 positron emission tomography (PET) in medication-free individuals with generalized SAD(More)
There is strong interest in investigating both functional connectivity (FC) using functional magnetic resonance imaging (fMRI) and structural connectivity (SC) using diffusion tensor imaging (DTI). There is also emerging evidence of correspondence between functional and structural pathways within many networks (Greicius, et al., 2009; Skudlarski et al.,(More)
PURPOSE To compare the diagnostic performance of the synthetic amino acid analog radiotracer anti-1-amino-3-fluorine 18-fluorocyclobutane-1-carboxylic acid (anti-3-(18)F-FACBC) with that of indium 111 ((111)In)-capromab pendetide in the detection of recurrent prostate carcinoma. MATERIALS AND METHODS This prospective study was approved by the(More)
Functional neuroimaging, including positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), plays an important role in identifying specific brain regions associated with experimental stimuli or psychiatric disorders such as schizophrenia. PET and fMRI produce massive data sets that contain both temporal correlations from repeated(More)
Complex functional brain network analyses have exploded over the last decade, gaining traction due to their profound clinical implications. The application of network science (an interdisciplinary offshoot of graph theory) has facilitated these analyses and enabled examining the brain as an integrated system that produces complex behaviors. While the field(More)
BACKGROUND Isoflurane administration is known to increase extracellular dopamine (DA) concentration. Because the dopamine transporter (DAT) is a key regulator of DA, it is likely affected by isoflurane. This study investigates the hypothesis that isoflurane inhibits DA reuptake by causing DAT to be trafficked into the cell. METHODS Rhesus monkeys were(More)