F. Andrew Ray

Learn More
Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the carcinogenic effects of 300 MeV/n 28Si or 600 MeV/n 56Fe ions in a mouse model for(More)
Chromosomal rearrangements are a source of structural variation within the genome that figure prominently in human disease, where the importance of translocations and deletions is well recognized. In principle, inversions—reversals in the orientation of DNA sequences within a chromosome—should have similar detrimental potential. However, the study of(More)
TnT: T antigen and telomerase, an explosive route to cancer * Sir, Early this century when Hanahan and Weinberg enumerated the six phenotypes that they defined as the 'Hallmarks of Cancer', they segregated genomic instability as 'an enabling characteristic' rather than defining it as a hallmark. Reading more carefully, we learn that they have set genomic(More)
  • 1