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PURPOSE Optogenetic fMRI (ofMRI) is a novel tool in neurophysiology and neuroimaging. The method is prone to light-induced artifacts, two of which were investigated in this study. METHODS ofMRI was performed in rats using two excitatory opsins (ChR2 and C1V1TT ) virally transduced in somatosensory cortex or thalamus. Heat-induced apparent BOLD activation(More)
The combination of optogenetic control and fMRI readout in the brain is increasingly used to assess neuronal networks and underlying signal processing. However, how exactly optogenetic activation or inhibition reproduces normal physiological input has not been fully unraveled. To assess details of temporal dynamics of the hemodynamic response, temporal(More)
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