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Phosphoenolpyruvate carboxykinase (EC 4.1.1.49) (PEPcK) activity is high in the liver, brown fat, and small intestinal mucosa of suckling rats. Starvation results in a rise in hepatic activity in newborn and older animals, but a fall in brown fat from rats younger than 14 days. At that age, activity rises in all three tissues on fasting. Both(More)
Phosphoenolpyruvate carboxykinase activity was found to be high in the mucosa of the small intestine of suckling rats. Activity was higher proximally than distally and decreased to very low values at weaning. After weaning, feeding a high fat diet or starvation did not result in elevation of the low intestinal activity in rats. However, in mice, who also(More)
3-Hydroxy-3-methylglutarylCoA reductase activity was found to be low in the microsomal fraction of the small intestine, liver, and brown fat in suckling rats. It was high perinatally. Treatment with phosphatase of the microsomal fraction increased activity considerably in gut, somewhat in liver, and not al all in brown fat of infant rats. Activity in the(More)
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