F. A. Macrae

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We studied 17,576 members of 166 MLH1 and 224 MSH2 mutation-carrying families from the Colon Cancer Family Registry. Average cumulative risks of colorectal cancer (CRC), endometrial cancer (EC), and other cancers for carriers were estimated using modified segregation analysis conditioned on ascertainment criteria. Heterogeneity in risks was investigated(More)
BACKGROUND Carriers of germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), but the modifiers of this risk are not well established. We estimated an association between body mass index (BMI) in early adulthood and subsequent risk of CRC for carriers and, as a comparison, estimated the association for(More)
Sir-The above paper by Turunen et al. (1984) provides interesting data about the relative sensitivities of FECA-EIA, an immunological test for human haemoglobin (Hb), and four guaiac tests for the detection of faecal occult blood. The authors also present data on blood loss in 19 patients with colorectal cancer. The observation that blood loss from cancers(More)
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