Félix O Dupont

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Fabry disease is an X-linked, multisystemic lysosomal storage disorder due to alpha-galactosidase A deficiency. It is characterized by the accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb(3)), in biological fluids, vascular endothelium, heart, and kidneys. Treatment by enzyme replacement therapy has been shown to be beneficial in both(More)
We study the advection of passive tracers by traveling plane Rossby waves of finite amplitude. In distinction with previous studies the nonlinearity of the wave field is taken into account in the first order of perturbation theory by considering the Lagrangian transport by resonant wave triads. Using the waves' phases as new dynamical variables we reduce(More)
Three jet events arising from decays of the Z bo-son, collected by the DELPHI detector, were used to measure differences in quark and gluon fragmentation. Gluon jets were anti-tagged by identifying b quark jets. Unbiased quark jets came from events with two jets plus one photon. Quark and gluon jet properties in different energy ranges were compared for the(More)
[1] Satellite-passive microwave remote sensing has been extensively used to estimate snow water equivalent (SWE) in northern regions. Although passive microwave sensors operate independent of solar illumination and the lower frequencies are independent of atmospheric conditions, the coarse spatial resolution introduces uncertainties to SWE retrievals due to(More)
Fabry disease is a lysosomal storage disorder caused by deficiency of α-galactosidase A, resulting in glycosphingolipid accumulation in organs and tissues, including plasma and urine. Two disease-specific Fabry biomarkers have been identified and quantified in plasma and urine: globotriaosylceramide (Gb(3)) and globotriaosylsphingosine (lyso-Gb(3)). The(More)
OBJECTIVE The lifetime risk of metabolic diseases in offspring of women with gestational diabetes mellitus (GDM) depends, at least in part, on the impact of glycemic fetal programming. To quantify this impact, we have developed and validated a unique mass spectrometry method to measure the percentage of glycated hemoglobin in cord blood. RESEARCH DESIGN(More)
[1] Observations indicate that the occurrence of dense upper-ocean water masses coincides with periods of intense deep-water formation in the Greenland Sea. This paper focuses on the upper-ocean hydrography of the area and its simulation in models. We analyze properties that reside below the summer mixed layer at 200 m and carry the winter mixing signal.(More)
The Production of neutron-rich radioactive nuclei through fission is currently prime of research interest for the future radioactive beam facilities. For example in the EURISOL[1] project, photo-fission and fast neutron induced fission are proposed. The photo-fission cross-section for 238 U is about 0.16 barn (against 1.6 barn for fast neutrons of 40 MeV)(More)
The N-methoxy-N-methyl bis(2,2,2-trifluoroethyl)phosphonamide was easily obtained via the Arbuzov reaction with use of commercially available tris(2,2,2-trifluoroethyl)phosphite, 2-bromo-N-methoxy-N-methylacetamide, and KF/alumina. The reaction of bis(2,2,2-trifluoroethyl)phosphonate with several aldehydes demonstrates the versatility of the method, which(More)