Ezra G. Baraban

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Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. In ApoE(-/-) mice, selective arginase II(More)
Emerging evidence supports the idea that arginase, expressed in the vascular endothelial cells of humans and other species, modulates endothelial nitric oxide (NO) synthase-3 (NOS-3) activity by regulating intracellular L-arginine bioavailability. Arginase II is thought to be expressed in the mitochondria of a variety of nonendothelial cells, whereas(More)
A number of cases of allogeneic hematopoietic stem cell transplant (allo-HCT) patients presenting with donor-derived neoplasms (DDN) has been reported. Even if the morphological findings were identical, host-derived therapy-related myeloid neoplasms (t-MN) and DDN are distinct diseases, with potentially different treatments. However, the current World(More)
Laboratorians are well accustomed to the practice of quality control (QC) with Levy-Jennings plots, both prior to and following analytical runs. One limitation of Levy-Jennings plots is that they represent QC at a single moment in time and are insensitive to error between QC runs. Currently, laboratory information systems, middleware systems, and laboratory(More)
The dearth of new antibiotics in the face of widespread antimicrobial resistance makes developing innovative strategies for discovering new antibiotics critical for the future management of infectious disease. Understanding the genetics and evolution of antibiotic producers will help guide the discovery and bioengineering of novel antibiotics. We discovered(More)
Endophytes isolated from tropical plants represent a largely untapped reservoir of bioactive secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of the plant pathogen, Pythium ultimum, and purified an active compound using bioassay-guided fractionation. A new nonenolide,(More)
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