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  • Eyad Kalawy Fansa, Stefanie Kristine Kösling, Eldar Zent, Alfred Wittinghofer, Shehab A. Ismail
  • Biology, Medicine
  • Nature communications
  • 2016 (First Publication: 11 April 2016)
  • The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood. Here we showContinue Reading
  • Mamta Jaiswal, Eyad Kalawy Fansa, Stefanie Kristine Kösling, Tom Mejuch, Herbert Waldmann, Alfred Wittinghofer
  • Chemistry, Biology, Medicine
  • The Journal of Biological Chemistry
  • 2016 (First Publication: 1 August 2016)
  • Primary cilia are highly specialized small antenna-like cellular protrusions that extend from the cell surface of many eukaryotic cell types. The protein content inside cilia and cytoplasm is veryContinue Reading
  • Harish C. Thakur, Madhurendra Singh, +11 authors Roland P. Piekorz
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2013 (First Publication: 22 November 2013)
  • Background: The TACC3-chTOG protein complex is essential for mitotic spindle assembly. Results: TACC3-chTOG binding is directed and mediated by specific intradomain and interdomain interactions thatContinue Reading
  • Pablo Martín-Gago, Eyad Kalawy Fansa, +10 authors Herbert Waldmann
  • Chemistry, Medicine
  • Angewandte Chemie
  • 2017 (First Publication: 20 February 2017)
  • Small-molecule inhibition of the interaction between the KRas oncoprotein and the chaperone PDE6δ impairs KRas spatial organization and signaling in cells. However, despite potent binding in vitroContinue Reading