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BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients
Each region of chromosome 11q22-23 should be considered in the future diagnostics of CLL in order to aid treatment decisions, notably whether to treat with or without fludarabine.
Comprehensive chronic lymphocytic leukemia diagnostics by combined multiplex ligation dependent probe amplification (MLPA) and interphase fluorescence in situ hybridization (iFISH)
Both MLPA and routine iFISH have comparable detection rates for aberrations being typically present in CLL and both were superior to MLPA in samples with low tumor cell load, and thus a cost-efficient scheme for routine diagnostics is proposed.
The current state of molecular cytogenetics in cancer diagnosis
- T. Liehr, M. Othman, K. Rittscher, Eyad Alhourani
- BiologyExpert Review of Molecular Diagnostics
- 20 March 2015
A historical perspective of molecular tumor cytogenetics is provided, which is followed by the basic principles of the fluorescence in situ hybridization (FISH) approach, and the current state of molecular cytogenetic in cancer diagnostics is discussed.
Isochromosome 17q in Chronic Lymphocytic Leukemia
- Eyad Alhourani, Martina Rinčić, T. Liehr
- Medicine, BiologyLeukemia research and treatment
- 30 November 2015
Interestingly, the cases with i( 17q) showed a tendency towards more associated chromosomal aberrations, and it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone.
A Novel Three-Way Variant t(8;13;21)(q22;q33;q22) in a Child with Acute Myeloid Leukemia with RUNX1/RUNX1T1: The Contribution of Molecular Approaches for Revealing t(8;21) Variants
A child with AML harboring a novel three-way cryptic variant t(8; 13; 21), as revealed by detailed molecular studies is reported on.
Stimulation of Suicidal Erythrocyte Death by Ipratropium Bromide
Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca2+-entry.
A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia
A case of 26-year-old male diagnosed with T-cell acute lymphoblastic leukemia and considered to have a normal karyotype after low resolution banding cytogenetics was studied retrospectively in detail by molecular cytogenetic and molecular approaches.
Interphase Molecular Cytogenetic Detection Rates of Chronic Lymphocytic Leukemia–Specific Aberrations Are Higher in Cultivated Cells Than in Blood or Bone Marrow Smears
- Eyad Alhourani, R. Aroutiounian, T. Liehr
- BiologyThe journal of histochemistry and cytochemistry…
- 17 June 2016
The obtained results implicate that iFISH directly applied on smears is in general less efficient for the detection of CLL-specific genetic abnormalities than for cultivated cells and shows that applied cell culture conditions are well suited for malignant CLL cells.
MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report.
Even if this complex karyotype would have be identified at the time of diagnosis, most likely no other protocol of anticancer therapy (ALL-BFM 95) would have been applied.
Isochromosome 17 q in Chronic Lymphocytic Leukemia
This poster presents a probabilistic procedure called “spot-spot analysis” that allows for direct measurement of the FISH signal in the nucleus of the brain during the development of Alzheimer's disease.