Ewan O'Sullivan

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One hundred and sixty patients have been studied in a controlled trial of two drugs which have been in combination to prevent postoperative-deep-vein thrombosis. Both the drugs, dipyridamole (Persantin) and aspirin, were given by mouth from the evening before operation and for seven days after operation. The radioactive fibrinogen test was used to diagnose(More)
Fourteen patients were treated with anticoagulants during 15 pregnancies. Eleven had venous thrombosis, three with pulmonary embolism; three had prosthetic heart valves; and one had mitral stenosis with pulmonary hypertension. All 15 were treated with heparin and 10 with warfarin. The mean duration of heparin therapy was 4.5 weeks and of warfarin 14 weeks.(More)
We present the results of an X-ray mass analysis of the early-type galaxy NGC 4636, using Chandra data. We have compared the X-ray mass density profile with that derived from a dynamical analysis of the system's globular clusters (GCs). Given the observed interaction between the central active galactic nucleus and the X-ray emitting gas in NGC 4636, we(More)
1. Patients suffering trauma and sepsis are insulin resistant, but no studies have specifically been made of patients suffering multiple organ failure. 2. We have studied exogenous glucose utilization in multiple organ failure using a combination of the hyperglycaemic glucose clamp and indirect calorimetry to quantify glucose utilization in multiple organ(More)
The extent of early resolution of major pulmonary embolism observed in 10 patients after 24 hours of treatment with heparin was compared with that seen in 17 patients after 24 hours of treatment with streptokinase. The patients in the streptokinase group also received a loading dose of heparin and were treated with heparin by continuous infusion when their(More)
OBJECTIVES To determine whether glucose utilization and metabolic substrate (glucose and fat) oxidation could be manipulated in patients with secondary multiple organ dysfunction syndrome. DESIGN Prospective study. SETTING Intensive care units (ICU) of two university hospitals. PATIENTS Eight adults free of hepatic disease and hemodynamically stable(More)
BACKGROUND Sleeping with the head of bed tilted upwards (SHU) is recommended as a treatment of orthostatic hypotension though the supporting evidence is weak. AIM To investigate the physiological effects of SHU amongst a group of young healthy volunteers. METHODS Twenty-nine volunteers, mean age 22 years, underwent 1-week of SHU at 18-in. elevation.(More)