Ewald G. J. Reinders

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Allergic or anaphylactic-like reactions have been reported with cis-dichlorodiammineplatinum(II) (CDDP) administration. We have seen two reactions among 50 patients treated in a phase II trial of CDDP. Both patients were successfully rechallenged after diphenhydramine pretreatment, and therapy was continued. In vivo and in vitro studies performed in one(More)
The aim of this paper is to describe a device for flow proportional injection of tracer gas in the lungs of mechanically ventilated patients. This device may then be used for the study of the multiple breath indicator gas washout technique to determine the end-expiratory lung volume. Such a tracer gas injection device may also be used in the study of other(More)
A simple and commercially available automated technique for fluorometric analysis of histamine is described. It is applicable to histamine release experiments utilizing washed leukocytes, and analyzes 15 samples/h at histamine concentrations between 1 and 1000 ng/ml with a mean variance between 0.5% and 18%. This technique is applied to a cross sectional(More)
The study presents the results of the development of an analyser to measure sulphur hexafluoride (SF6) gas in breathing circuits, for application is studies of lung function. The analyser consists of an in-line breathing circuit measurement transducer and a compact unit for signal treatment. The detector unit of the analyser consists of a near-infrared(More)
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