Ewa Mendek-Czajkowska

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The glycolipid glycosylphosphatidylinositol anchor (GPI-A) plays an important role in lipid raft formation, which is required for proper expression on the cell surface of two inhibitors of the complement cascade, CD55 and CD59. The absence of these markers from the surface of blood cells, including erythrocytes, makes the cells susceptible to complement(More)
We present three novel mutations in the G6PD gene and discuss the changes they cause in the 3-dimensional structure of the enzyme: 573C-->G substitution that predicts Phe to Leu at position 191 in the C-terminus of helix alphae, 851T-->C mutation which results in the substitution 284Val--> -->Ala in the beta+alpha domain close to the C-terminal part of(More)
The mechanisms of MHC allele associations with paroxysmal nocturnal hemoglobinuria (PNH) and its aplastic anemia subtype (AA/PNH) remain unclear. It might be dependent on MHC molecule functional properties, such as a scope and frequency of antigen sampling and presentation. For documented PNH-associated MHC alleles we analyzed current reference databases on(More)
The therapeutic efficacy of thalidomide ñ a derivative of glutamic acid ñ has been studied in numerous trials on refractory/relapsed multiple myeloma (MM) patients (1, 2). They showed that single-agent thalidomide can induce a partial response in approximately 30% of patients with refractory myeloma. The combination of thalido-mide with dexamethasone is(More)
153 Adres do korespondencji: Adres do korespondencji: Adres do korespondencji: Adres do korespondencji: Adres do korespondencji: lek. Abstract Methemoglobinemia; an increased concentration of methemoglobin in the blood, is an altered state of hemoglobin whereby the ferrous form of iron is oxidized to the ferric state, rendering the heme moiety incapable of(More)
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