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The Tie-2 ligand angio-poietin-2 is stored in and rapidly released upon stimulation from en-dothelial cell Weibel–Palade bodies. et al. Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothe-lial cells. The Tie-2 ligand angio-poietin-2 destabilizes quiescent endothelium through an internal autocrine loop(More)
BACKGROUND Low blood counts of CD34/kinase-insert domain receptor double-positive cells (CD34(+)/KDR(+) cells)-a leukocytes subpopulation enriched for bone marrow-derived endothelial progenitor cells (EPC)- predict adverse outcomes in coronary artery disease (CAD). The dependence of EPC numbers on the glomerular filtration rate (GFR), another prognostic(More)
Secretory leukocyte proteinase inhibitor (SLPI) is a well-established inhibitor of serine proteases such as human neutrophil elastase (HNE) and a NF-κB regulatory agent in immune cells. In this paper, we report that SLPI plays a previously uncharacterized role in regulating activation of plasmacytoid dendritic cells (pDCs). As the main source of IFN type I(More)
AIM To assess endothelial progenitor cells (EPC) counts, a novel prognostic marker, in relation to classical adverse outcome predictors - N-terminal pro-B-type natriuretic peptide (NT-proBNP), impaired left ventricular (LV) relaxation and exercise-induced ischemia - in stable coronary artery disease (CAD) with preserved LV systolic function. METHODS We(More)
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