Ewa K. Blaszczak

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The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane is continuous with the endoplasmic reticulum and is the site of membrane protein synthesis. Protein(More)
Ubiquitylation is a versatile posttranslational protein modification catalyzed through the concerted action of ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s). These enzymes form transient complexes with each other and their modification substrates and determine the nature of the ubiquitin signals attached to their substrates. One challenge(More)
Protein quality control mechanisms protect cells from defective, mislocalized or supernumerary proteins. The clearance of those proteins is achieved by intracellular degradation pathways, among which the ubiquitin-proteasome system is a major player. In this system, proteins to be degraded are labeled through the covalent attachment of ubiquitin. This is(More)
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