Ewa Jakimiuk

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The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 microg T-2 toxin kg(-1) feed) on percentages of(More)
The immunological, haematological and biochemical analyses of blood plasma in bitches with 50 days lasting induced zearalenone micotoxicosis were carried out. It can be indirectly suggested that the inhibition of the humoral reaction of the organism, stimulation of detoxification effect in the liver and decreased cellular answer took place.
Fusarium spp. moulds are common in moderate climate regions of North America, Asia and Europe. They produce hepatotoxic and nephrotoxic mycotoxins, acting like estrogens, impairing hemopoesis and immunosuppressing. Actively dividing skin cells, lymphatic tissue, haemopoetic tissue and gastrointestinal tissue are the most sensitive for these trichothecenes(More)
Farm animals are at risk of exposure to zearalenone (ZEA) in feedstuffs, which may lead to aberrations in their reproductive development, thereby adversely affecting production outcomes. The objective of this study was to determine the effect of long-term (48 days), per os administration of low ZEA doses (50% [20 μg ZEA/kg body weight (bw)] and 100% [40 μg(More)
Both earlier investigations and complete formulas of pet food for dogs show that professionally prepared pet food is based in 30% on the material of the plant origin. Our own investigations prove that animal feeding stuffs of the plant origin are very often vectors of many undesirable substances (including micotoxins) that are unfavourable for carnivores.(More)
Zearalenone (ZEA) is a mycoestrogen frequently found in food and animal feed materials all over the world. Despite its hydrophobic character, ZEA is also found in surface and ground waters which suggests an environmental risk for aquatic animals. Knowledge concerning mycotoxin-related mechanisms of toxicity is still incomplete, e.g. little is known about(More)
Zearalenone (ZEA) is a mycotoxin produced by Fusarium. It evokes disruptions in sex cycle and changes in the morphology of the reproductive organs in pigs. The morphology and ultrastructure of the small intestine mucosa were assessed after the course of the experimental zearalenone mycotoxicosis. During the experiment, pigs were fed feed containing low(More)
The objective of this study was to determine whether long-term (48-day) oral administration of low-dose zearalenone (ZEA) resulted in changes in uterine histology in sexually immature gilts. The study involved 12 clinically healthy 2-month-old gilts with a determined immune status. The animals were randomly divided into two experimental groups (E1, n=4; E2,(More)
Among large husbandry animals, swine are the most predisposed to zearalenone (ZEA) intoxication, mainly because cereal is an important component of their diet. Studies performed so far (in vivo, in vitro) suggest that ZEA and its metabolites, which may appear due to ZEA biotransformation (especially alpha-zearalenole; alpha-ZOL), can modify signaling(More)
The aim of the study was to determine how a low dose of zearalenone applied orally for eight days influences the level of zearalenone (ZEN) and alpha-zearalenole in blood plasma and causes the occurrence of histopathological changes in the cells of the ovarian follicles in sexually immature gilts. The animals were divided into 2 groups (control, C; n = 4(More)