Ewa Emich-Widera

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Drug-resistant epilepsies still remain one of the most profound problems of contemporary epileptology. Several mechanisms of drug resistance are possible; among them, genetic factors have a prominent place. Much importance is attached to genes, which encode enzymes that metabolize antiepileptic drugs CYP 3A, which belong to the family of cytochromes P450(More)
BACKGROUND The investigation of a possible association between the FII, FV, FVII, and FXIII genes polymorphisms and pediatric ischemic stroke (IS). METHODS The study group consisted of 392 individuals, including 81 children with IS, their biological parents (n=162), and 149 control children. The polymorphisms were genotyped using polymerase chain(More)
Moderate hyperhomocysteinemia is one of the risk factors of pediatric stroke. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme, which regulates homocysteine metabolism, and some polymorphisms of gene encoding this enzyme are associated with a decreased activity of the enzyme. The aim of the study was to assess an association between the(More)
BACKGROUND The diagnosis of "drug resistance" in epilepsy can be defined and interpreted in various ways. This may be due to discrepant definitions of drug resistance to pharmacotherapy. The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different(More)
Background Early detection of movement deficits during step initiation will facilitate the selection of the optimal physiotherapy management strategy. The main aim of the study was to assess potential differences in step initiation between 5- and 6-year-old children with faulty posture who had been diagnosed with neurodevelopmental disorders during infancy(More)
Tuberculosis of the central nervous system possess a serious clinical and radiological problem, since early treatment of this condition is crucial for the patient's life, and tuberculous process in the CNS may mimic many other pathologies. In this paper three cases of tuberculous process difficult to diagnose are presented. In all the cases early treatment(More)
BACKGROUND AND PURPOSE Reactive oxygen species play an important role in the physiology and pathology of cerebral arteries, including ischaemic stroke. The cytochrome b-245 alpha gene (CYBA) encodes cytochrome b-245 alpha light chain (p22phox peptide), a critical element of NAD(P)H oxidases, the most important source of superoxide anion in the cerebral(More)
STRESZCZENIE Celem pracy jest identyfikacja najistotniejszych wskazań do przeprowadzenia badań naczyń mózgowych metodą Dopplera u dzieci. Materiał, metoda. Badaniem objęto 140 pacjentów w wieku od 8 miesiąca do 18 roku życia (93 dziewczynki i 47 chłopców). Wskazaniami do hospitalizacji w Klinice Neurologii Wieku Rozwojowego były: bóle głowy, omdlenia,(More)
PURPOSE The aim of this study is to find the relationship between visual function changes and vigabatrin treatment continuation or discontinuation. MATERIAL AND METHODS 19 patients (11 males, 8 females) from 8 to 20 years old, treated with vigabatrin because of partial epilepsy, were examined. Best corrected visual acuity, contrast sensitivity and static(More)
One of the leading positions on the world's list of harmful substances is taken by cadmium, which is a heavy metal. Cadmium (Cd) gets into the human body through either respiratory tract (cigarette smoke) or alimentary canal. The aim of the study was to 1) determine whether the concentrations of cadmium in blood and urine of children from Katowice(More)