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INTRODUCTION The STAT3 gene functions as both the oncogene and the regulator of immunity. Despite its important role in cancer development and regulation of the immune cells, studies of single… (More)
Congenital hypothyroidism (CH) occurs approximately with a frequency of 1 in 3000-4000 births, being a disease caused by defects in thyroid hormone synthesis associated either with goiter presence or… (More)
The inflammatory process in systemic lupus erythematosus (SLE) affects many organs including the lungs. CXC chemokines are suggested to play an important role in the pathogenesis of SLE and pulmonary… (More)
was to analyse the methylation profile of the eight tumour suppressor genes (TSGs) ARHI, CDH1, KCNQ1, MEST, p16INK4A, RASSF1A, SLC5A8 and VHL in noncancerous thyroid tissue adjacent to papillary… (More)
Introduction: The aim of this study was to analyse the loss of heterozygosity (LOH) and microsatellite instability (MSI) at the thyroid hormone receptor beta (THRB) locus (3p24.3) and in the… (More)
Transforming growth factor beta 1 (TGFB1) stimulates the production of various extracellular matrix components; at the same time, it inhibits matrix degradation. These actions of TGFB1 contribute to… (More)