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Local Anesthetics Potentiate Spinal Morphine Antinociception
Some investigators have postulated a synergistic analgesic effect of local anesthetic agents and opiates when given intrathecally or epidurally, but little objective evidence has been presented toExpand
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Complete blockade and attenuation of 5-hydroxytryptamine induced analgesia following NA depletion in rats and mice.
The effect of pretreatment with the noradrenaline neurotoxin, N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), upon the analgesia induced by various doses of 5-hydroxytryptamine (5-HT) was examinedExpand
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Noradrenaline depletion increases noradrenaline-induced antinociception in mice
Mice were treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4), which causes severe noradrenaline (NA) depletions in brain regions and the spinal cord, or vehicle i.p. TheyExpand
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(+)-8-OH-DPAT and 5-MeODMT induced analgesia is antagonised by noradrenaline depletion
In experiments with both rats and mice the 5-HT agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT) were shown to produce reliable analgesicExpand
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