Ewa A Marewicz

Learn More
OBJECTIVE Similarities between rheumatoid arthritis (RA) and atherosclerosis include endothelial dysfunction (an antecedent of plaque formation) and depletion of circulating bone marrow-derived endothelial progenitor cells. This study was undertaken to test the hypothesis that endothelial progenitor cell depletion and subclinical atherosclerosis in RA may(More)
Secretory leukocyte proteinase inhibitor (SLPI) is a well-established inhibitor of serine proteases such as human neutrophil elastase (HNE) and a NF-κB regulatory agent in immune cells. In this paper, we report that SLPI plays a previously uncharacterized role in regulating activation of plasmacytoid dendritic cells (pDCs). As the main source of IFN type I(More)
Background. Little information is available about the ef-<lb>ficacy of tonsillectomy on long-term renal survival of pa-<lb>tients with primary IgA nephropathy (IgAN).<lb>Methods. In this retrospective cohort study, we considered<lb>61 patients with IgAN who had tonsillectomy (n = 15) or<lb>not (n = 46) and compared them with 121 control patients<lb>with(More)
BACKGROUND Renal insufficiency predisposes to coronary artery disease (CAD), but also CAD and traditional risk factors accelerate renal function loss. Endothelial progenitor cell (EPC) deficiency and elevated asymmetrical dimethyl-L-arginine (ADMA), an endogenous nitric oxide (NO) formation inhibitor, predict adverse CAD outcome. Our aim was to assess(More)
Macrophages have the potential to recognize apoptotic neutrophils and phagocytose them while the same function for monocytes is uncertain. In fact, early findings indicated that monocytes started to phagocytose neutrophils on the third day of differentiation to macrophages. Here we show, using flow cytometry and confocal microscopy, that peripheral blood(More)
The infection of human skin fibroblasts grown in culture with Candida albicans causes the death of infected cells, as assayed with the trypan blue exclusion test. The cell death is preceded by: (1) an attachment of germ tubes to the perinuclear surface of fibroblasts; (2) the disappearance of stress fibers and the disorganization of F-actin cytoskeleton and(More)
BACKGROUND Low blood counts of CD34/kinase-insert domain receptor double-positive cells (CD34(+)/KDR(+) cells)-a leukocytes subpopulation enriched for bone marrow-derived endothelial progenitor cells (EPC)- predict adverse outcomes in coronary artery disease (CAD). The dependence of EPC numbers on the glomerular filtration rate (GFR), another prognostic(More)
AIM To assess endothelial progenitor cells (EPC) counts, a novel prognostic marker, in relation to classical adverse outcome predictors - N-terminal pro-B-type natriuretic peptide (NT-proBNP), impaired left ventricular (LV) relaxation and exercise-induced ischemia - in stable coronary artery disease (CAD) with preserved LV systolic function. METHODS We(More)
  • 1