Evgeny Shlevkov

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A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila

Evgeny Shlevkov, Gérald Morata
Cell Death and Differentiation
2012

Programmed cell death (apoptosis) is a conserved process aimed to eliminate unwanted cells. The key molecules are a group of proteases called caspases that cleave vital proteins, which leads to the… (More)

The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc.

Ainhoa Pérez-Garijo, Evgeny Shlevkov, Ginés Morata
Development
2009

Non-lethal stress treatments (X-radiation or heat shock) administered to Drosophila imaginal discs induce massive apoptosis, which may eliminate more that 50% of the cells. Yet the discs are able to… (More)

Mitogenic signaling from apoptotic cells in Drosophila.

Ginés Morata, Evgeny Shlevkov, Ainhoa Pérez-Garijo
Development, growth & differentiation
2011

Apoptotic cells of Drosophila not only activate caspases, but also are able to secrete developmental signals like Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) before dying. Since Dpp and Wg… (More)

Have you seen? For parkin, it's not all or nothing.

Evgeny Shlevkov, T. Schwarz
The EMBO journal
2014

Mitochondria accumulate damage over time, which can lead to impairment of cell function by excessive production of reactive oxygen species. The PINK1/Parkin pathway therefore monitors the quality of… (More)

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.

Evgeny Shlevkov, Tal Kramer, Jason Schapansky, Matthew J Lavoie, T. Schwarz
Proceedings of the National Academy of Sciences…
2016

The PTEN-induced putative kinase 1 (PINK1)/Parkin pathway can tag damaged mitochondria and trigger their degradation by mitophagy. Before the onset of mitophagy, the pathway blocks mitochondrial… (More)

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