Evgeny Fink

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Ninety-three mongrel dogs underwent intracranial carotid and middle cerebral artery occlusions. They were then randomized into four groups: 1) the untreated control group (no surgical or medical therapy) showed significant neurological deficit, 16% mortality, and 17% mean hemisphere infarction; 2) in the bypass group (superficial temporal to middle cerebral(More)
Cerebrovascular and cardiac alterations evoked by intravascular volume expansion with low molecular weight dextran (LMD, molecular weight 40,000), an advocated adjunct in the clinical prevention or therapy of acute stroke and cerebral vasospasm, were studied in splenectomized dogs. Clipping of the right distal internal carotid artery and the proximal middle(More)
OBJECTIVES We have demonstrated previously that former opiate-dependent subjects treated and detoxified from methadone maintenance therapy suffer deficits in neuropsychological performance and have abnormal pain thresholds. This study examined the impact of pain on the performance of the Stroop test, a well-known test of neuropsychological performance. (More)
Unilateral clipping of cerebral arteries in eight dogs reduced regional cortical blood flow (rCoBF) without altering cardiac output (CO) or intracranial pressure (ICP) and resulted in 10% hemispheric infarction. In ten dogs, total blood volume (TBV), CO, rCoBF in the region of the occluded artery, and ICP increased while the hematocrit (Hct) decreased(More)
Barbiturates were administered to normal dogs, establishing an isoelectric electrocorticogram. Cortical cerebral blood flows (CBF) and deeper CBF's were respectively measured by krypton-85 (85Kr) and xenon-133 (133 Xe). Following barbiturate administration, the two methods of measuring CBF showed a poor coefficient of variation (r=0.12, p less than 0.05).(More)
A reliable method of macroscopically determining the volume of cerebral infarction using ultraviolet fluorescence was developed in an animal model. Cerebral infarction was induced in 40 dogs by occluding the distal internal carotid and middle cerebral arteries. No barbiturates were administered. Intravenous sodium fluorescein was given before the animal was(More)
Mice were exposed to lead acetate (0.5%) pre- and postnatally, and activity levels were assessed at 21 days of age. Two measures of open field activity were employed at two different times of day across three doses of d-amphetamine. These factors influence the results observed in lead exposed mice and demonstrate that lead's effects on activity are not(More)
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