Evgenij Loukianov

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We used an exon-specific gene-targeting strategy to generate a mouse model deficient only in the SM-B myosin isoform. Here we show that deletion of exon-5B (specific for SM-B) in the gene for the heavy chain of smooth muscle myosin results in a complete loss of SM-B myosin and switching of splicing to the SM-A isoform, without affecting SM1 and SM2 myosin(More)
Cardiac hypertrophy and heart failure are known to be associated with a reduction in Ca-ATPase pump levels of the sarcoplasmic reticulum (SR). To determine whether, and to what extent, alterations in Ca pump numbers can affect contraction and relaxation parameters of the heart, we have overexpressed the cardiac SR Ca-ATPase specifically in the mouse heart(More)
The ATP2A2 gene encodes the sarco(endo)plasmic reticulum Ca-transport ATPase 2 (SERCA2), which is important for intracellular Ca homeostasis within eukaryotic cells. The ATP2A family of Ca ATPases establish and maintain intracellular Ca signaling stores through the ATP-dependent accumulation of cytosolic Ca into the endoplasmic/sarcoplasmic reticulum(More)
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