Evgenia Korytnaya

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The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose(More)
BACKGROUND The diagnosis of ectopic pituitary hormone secretion requires abnormally high circulating hormone levels, absence of a pituitary tumor, and localization of the hormone in question to the extrapituitary malignant neoplasm. No case of a malignant solid tumor producing prolactin has been documented thus far. CASE REPORT A 47-year-old woman(More)
Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKKɛ and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKKɛ and TBK1, in a proof-of-concept randomized, double-blind,(More)
OBJECTIVE To present a case of hypercalcemia associated with thyrotoxicosis in a patient with vitamin D deficiency and review biochemical changes during the course of treatment. METHODS We report a case, describe the changes in serum calcium, phosphorus, parathyroid hormone in Graves' disease and concomitant Vitamin D deficiency. We compare our findings(More)
Acromegaly is a chronic disease that in the great majority of cases is caused by Growth Hormone (GH) producing pituitary tumors and is characterized by high risk of mortality and a variety of morbidities. Goals of treatment of acromegaly include elimination of the mass effect of the tumor, which ideally would result in a complete disappearance of tumor(More)
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