Evgenia Freis

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PURPOSE Members of the Bcl-2 family act as master regulators of mitochondrial homeostasis and apoptosis. We analyzed whether ERBB2 influences the prognosis of breast cancer by influencing the proapoptotic versus antiapoptotic balance of Bcl-2 family members. EXPERIMENTAL DESIGN ERBB2-regulated Bcl-2 family members were identified by inducible expression(More)
INTRODUCTION The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. METHODS Analysis of the association of TXNRD1 and TXNIP RNA expression with the(More)
Worldwide, breast cancer is the second leading cause of cancer deaths in women. To gain insight into the processes related to the course of the disease, human genetic data can be used to identify associations between gene expression and prognosis. Moreover, the expression data of groups of genes may be aggregated to metagenes that may be used for(More)
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