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OBJECTIVE To investigate the predictive value of polycystic ovaries for endocrine signs of polycystic ovary syndrome (PCOS). DESIGN Controlled descriptive study. SETTING Academic tertiary care fertility clinic. PATIENT(S) Normogonadotropic (FSH levels between 1 and 10 mIU/mL conversion factor to SI unit, 1.0) oligomenorrheic or amenorrheic women(More)
OBJECTIVE To estimate the disease burden of the most important complications of postoperative abdominal adhesions: small bowel obstruction, difficulties at reoperation, infertility, and chronic pain. DESIGN Systematic review and meta-analyses. DATA SOURCES Searches of PubMed, Embase, and Central, from January 1990 to December 2012, without restrictions(More)
OBJECTIVE To study the relationship between decreasing serum FSH levels in the follicular phase of the normal menstrual cycle and follicle development by means of transvaginal sonography and E2 production. DESIGN Daily blood samples were taken and transvaginal sonography was performed every other day in 16 normal regularly cycling female volunteers. (More)
OBJECTIVE To assess the use rate and assisted reproductive technologies (ART) outcome of the cryopreserved semen of cancer patients with an average follow-up of 7 years (range, 2-23 years). DESIGN Retrospective data analysis. SETTING University-affiliated andrology and reproduction center. PATIENT(S) Six hundred twenty-nine male cancer patients who(More)
BACKGROUND Hysteroscopy is known as the most accurate test for diagnosing intrauterine pathology. To optimize fertility treatment, it is increasingly common to perform hysteroscopy as a routine procedure prior to IVF. However, literature on the reproducibility of screening hysteroscopy is lacking. Therefore, the aim of the study was to assess the intra- and(More)
OBJECTIVE To describe general and sexual well-being in women with premature ovarian failure (POF) and to investigate whether there is a relationship between androgen levels and sexual functioning. DESIGN Women with POF and healthy volunteers with regular menstrual cycles participated. Participants completed a written questionnaire and underwent hormonal(More)
OBJECTIVE To evaluate the ability of a prediction model to identify the individual starting dose of FSH for ovulation induction using a step-down regimen. DESIGN Retrospective analysis of clinical data in an academic fertility unit. Fifty-six normogonadotropic anovulatory infertile patients who failed to ovulate or conceive with clomiphene citrate were(More)
OBJECTIVE To assess whether the addition of metformin to gonadotrophin ovulation induction in insulin-resistant, normogonadotrophic, anovulatory women alters ovarian responsiveness to exogenous FSH. DESIGN Placebo-controlled double-blind assessment in an academic hospital. RESULTS After a progestagen withdrawal bleeding, patients were randomised for(More)
OBJECTIVE Earlier menopause is associated with a higher incidence of cardiovascular events later in life. Concurrent with the ages of menopausal transition, a shift in lipid profile takes place. Premature ovarian failure (POF) or premature menopause allows us to study the effect of cessation of ovarian function on the lipid profile independent of effects of(More)
OBJECTIVE To assess whether an FSH receptor polymorphism (Asn680Ser, rs6166) can affect the outcome of ovulation induction in normogonadotropic (World Health Organization class 2 [WHO2]) anovulatory subfertile women. DESIGN Prospective, longitudinal, cohort study. SETTING University-based fertility unit. PATIENT(S) A total of 240 consecutive women(More)