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1. We have investigated the modulation of N-methyl-D-aspartate (NMDA) receptor activation by the sulphydryl redox reagents dithiothreitol (DTT) and 5,5-dithio-bis-2-nitrobenzoic acid (DTNB). 2. Increases in [3H]-MK-801 binding produced by glutamate, glycine and spermidine were enhanced by DTT (2mM) and diminished by DTNB (0.5 mM). 3. The inhibition of(More)
The Atmospheric Radiation Measurement (ARM) Climate Research Facility (www.arm.gov) provides atmospheric observations from diverse climatic regimes around the world. Currently, ARM archives over 22 million user assessable data files, primarily stored in NetCDF file format, with total data volumes close to one Petabyte. In this paper, we will discuss how ARM(More)
The Department of Energy's (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility is establishing an adaptive data services and operations architecture in support of the Next-Generation ARM Facility as explained in its Decadal Vision. In this paper, we describe the capabilities of the ARM Data Center (ADC) and the upcoming high-performance(More)
We have examined the hypothesis that phenothiazines and tricyclic antidepressants interact with the N-methyl-D-aspartate (NMDA) receptor by mimicking the actions of Zn2+. Using [3H]MK801 binding to well-washed rat brain membranes, we found a disparity between the concentrations of drug required to inhibit [3H]MK801 binding and those necessary to alter(More)
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