Evelyne Kretzschmar

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Auditory tuning curves of a small songbird, the great tit (Parus major), and of its principal avian predator, the European sparrowhawk (Accipiter nisus), were determined by an operant positive reinforcement conditioning procedure, using the method of constant stimuli. Thresholds were measured by the criterion of a 50% correct response and a d′ of 1.5 for(More)
BACKGROUND AND OBJECTIVES The aim of this study was to evaluate the quality of leucocyte-depleted plasma produced from leucocyte-depleted whole blood, stored for different periods of times before filtration through polyurethane filters. MATERIALS AND METHODS Whole blood was collected, from 48 voluntary donors, into quadruple blood bag sets with integrated(More)
This study investigates the effect of pre-analytic storage conditions on the laboratory evaluation of von Willebrand disease (VWD) and haemophilia. Samples from healthy controls and patients with VWD were stored as whole blood and as separated plasma, both at room temperature and on crushed ice, for two different time periods (3 or 6 h). In samples from(More)
BACKGROUND Single-amino-acid substitution Leu33Pro in the beta3-integrin is responsible for the formation of the human platelet antigen (HPA)-1. Alloimmunization against HPA-1a (beta3-Leu33) is the most frequent cause of neonatal alloimmune thrombocytopenia and posttransfusion purpura. STUDY DESIGN AND METHODS While HPA-1 genotyping a large cohort of(More)
Genotyping of human platelet antigens (HPAs) can be useful for the diagnosis and therapy of alloimmune thrombocytopenic syndromes such as neonatal alloimmune thrombocytopenic purpura, post-transfusion purpura and refractoriness to platelet transfusion therapy. We developed a single-tube method for HPA-5 genotyping on the LightCycler that combines(More)
BACKGROUND AND OBJECTIVES Pooled nucleic acid amplification techniques (NAT) and donor screening for anti-hepatitis C virus (HCV) have reduced the diagnostic window period of HCV infection in the blood donor population from about 12 to 1 or 2 weeks. During that time, HCV RNA is hardly detectable by pooled or individual donation NAT. Here we describe a case(More)
Im Experiment gelingt es, nach längeren Megaphengaben in Kombination mit einer zusätzlichen toxischen Noxe das typische Bild einer intrahepatischen Cholestase zu erzeugen. Dieser cholestatische Effekt des Megaphen läßt sich durch Choleretica (Synthobilin, Biliton) verhindern. Die sich daraus für die Klinik ergebenden Konsequenzen werden erörtert.
Im Modell des vonEger angegebenen AAT wird die Megaphenwirkung auf die Leber untersucht. 1. Megaphen allein kommt keine direkte toxische Wirkung auf die Leber zu. 2. In Kombination mit zusätzlichen toxischen Noxen sind schädigende Einflüsse auf die Cholerese zu erwarten, vor allem nach längerer Megaphenmedikation. In typischer Weise entsteht das Bild einer(More)
PURPOSE OF REVIEW The purpose of this paper is to propose the use of factor VIIa in treating severely bleeding patients. RECENT FINDINGS Recombinant factor VIIa was developed in 1988 to treat patients with haemophilia A or B and antibodies against factors VIII and IX, or patients with a spontaneous inhibitor against factors VIII and IX. Since then factor(More)
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