Evan Y. Li

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L-Threose is a significant degradation product of ascorbic acid at pH 7.0 in the presence of oxygen. When compared to several other ascorbate-derived degradation products, it had the greatest ability to glycate and crosslink lens proteins in vitro. To determine whether L-threose was formed in the lens, the sugars in a TCA-soluble extract from human lenses(More)
The in vitro actin polymerization assay was done as described using rhodamine-labelled rabbit skeletal muscle actin (Cytoskeleton). For in vivo shift experiments with the temperature-sensitive strains, cells were shifted to 36 8C for 180 min before and during collection. In in vitro shift assays, cells were grown at 25 8C (permissive temperature),(More)
L-Threose, a comparatively unstable aldose, is produced from L-ascorbic acid in the presence of oxygen and participates vigorously in Maillard reactions, even at comparatively mild conditions. In the present study, the degradation of L-threose at pH 7.0 alone, in the presence of N-alpha-acetyl-L-lysine, and at pH 2.0 alone at 37 degrees C was investigated(More)
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