Evan R Himes

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cytoprotective genes against oxidative and chemical insults. The lack of Nrf2 can induce pathologies in multiple organs. The aim of this study was to(More)
Osteoblast differentiation and migration are necessary for bone formation during bone remodeling. Mice lacking the proline-rich tyrosine kinase Pyk2 (Pyk2-KO) have increased bone mass, in part due to increased osteoblast proliferation. Megakaryocytes (MKs), the platelet-producing cells, also promote osteoblast proliferation in vitro and bone-formation in(More)
George Washington School of Medicine and Health Sciences, 2300 Eye Street NW, Washington DC 20037; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis IN 46202; Department of Medicine, Indiana University School of Medicine, Indianapolis IN, 46202; Department of Microbiology and Immunology, Indiana University School of(More)
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