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- Publications
- Influence
The solithromycin journey-It is all in the chemistry.
- P. Fernandes, Evan Martens, D. Bertrand, D. Pereira
- Medicine, Biology
- Bioorganic & medicinal chemistry
- 15 December 2016
The macrolide class of antibiotics, including the early generation macrolides erythromycin, clarithromycin and azithromycin, have been used broadly for treatment of respiratory tract infections. An… Expand
The antibiotic resistance crisis, with a focus on the United States
- Evan Martens, A. Demain
- Biology, Medicine
- The Journal of Antibiotics
- 1 March 2017
Beginning with the discovery of penicillin by Alexander Fleming in the late 1920s, antibiotics have revolutionized the field of medicine. They have saved millions of lives each year, alleviated pain… Expand
Antibiotics in late clinical development
- P. Fernandes, Evan Martens
- Medicine
- Biochemical pharmacology
- 1 June 2017
&NA; Most pharmaceutical companies have stopped or have severely limited investments to discover and develop new antibiotics to treat the increasing prevalence of infections caused by multi‐drug… Expand
Nature nurtures the design of new semi-synthetic macrolide antibiotics
- P. Fernandes, Evan Martens, D. Pereira
- Medicine, Biology
- The Journal of Antibiotics
- 30 November 2016
Erythromycin and its analogs are used to treat respiratory tract and other infections. The broad use of these antibiotics during the last 5 decades has led to resistance that can range from 20% to… Expand
Production of valuable compounds by molds and yeasts
- A. Demain, Evan Martens
- Biology, Medicine
- The Journal of Antibiotics
- 12 October 2016
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among microbial biochemists. He began his professional career as an organic chemistry PhD student at Nottingham… Expand
Platensimycin and platencin: promising antibiotics for future application in human medicine
- Evan Martens, A. Demain
- Biology, Medicine
- The Journal of Antibiotics
- 1 November 2011
Platensimycin and platencin are novel antibiotics produced by Streptomyces platensis. They are potent and non-toxic natural products active against Gram-positive pathogens, including… Expand
Platensimycin and Platencin: Promising Antibiotics for Future Application in Human Medicine
- Evan Martens, A. L. Demain
- Chemistry
- 13 March 2012
Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis
- M. Falzone, Evan Martens, +12 authors A. Demain
- Chemistry, Medicine
- Applied Microbiology and Biotechnology
- 11 September 2013
The actinomycete Streptomyces platensis produces two compounds that display antibacterial activity: platensimycin and platencin. These compounds were discovered by the Merck Research Laboratories,… Expand
An Overview of the Industrial Aspects of Antibiotic Discovery
- Evan Martens, A. Demain
- Biology
- 2017
Abstract Microorganisms have provided an essential role in the production of natural products, such as antibiotics. Antibiotics are often produced as secondary metabolites, compounds not required for… Expand
Useful Anti-Cancer Agents of Natural Product Origin
- Evan Martens, A. L. Demain
- 2018
For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the terrestrial and marine environments. The… Expand