Nanoparticle Toxicology.
- Wen Yang, Lin Wang, Evan M. Mettenbrink, P. DeAngelis, S. Wilhelm
- BiologyAnnual Review of Pharmacology and Toxicology
- 25 August 2020
This review explores and highlights the current state of nanotoxicology research with a focus on mechanistic understanding of nanoparticle toxicity at organ, tissue, cell, and biomolecular levels, and discusses nanotoxicity mechanisms, including generation of reactive oxygen species, nanoparticle disintegration, modulation of cell signaling pathways, and protein corona formation.
Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds.
- B. L. Roberts, Zachary C. Severance, Anthony W. G. Burgett
- Biology, ChemistryAntiviral Research
- 2 July 2019
Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake.
- Wen Yang, Lin Wang, S. Wilhelm
- Biology, ChemistryNano letters (Print)
- 15 February 2022
It is found that the HEP-coating reduced the nanoparticle protein corona formation as efficiently as PEG coatings upon serum incubation, and HEP polymers may be an effective surface modification technology for nanomedicines to safely and efficiently target certain innate immune cells.
Controlling Nanoparticle Uptake in Innate Immune Cells with Heparosan Polysaccharides.
- Wen Yang, Alex N Frickenstein, S. Wilhelm
- Biology, ChemistryNano letters (Print)
- 1 September 2022
A substantial potential is suggested for HEP-coated nanoparticles to target innate immune cells for efficient intracellular delivery, including into the cytoplasm, through systematically varying the HEP surface density.
Bioimaging with Upconversion Nanoparticles
- Evan M. Mettenbrink, Wen Yang, S. Wilhelm
- BiologyAdvanced Photonics Research
- 9 September 2022
This review explores and discusses the opportunities, challenges, and limitations that UCNPs exhibit as bioimaging probes and highlights applications with spatial dimensions ranging from the single nanoparticle level to cellular, tissue, and whole animal imaging.