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New insights into the mechanism of action of amphetamines.

• Annette E. Fleckenstein, Trent J. Volz, Evan L. Riddle, James W. Gibb, Glen R. Hanson
• Annual review of pharmacology and toxicology
• 2007

Amphetamine is a psychostimulant commonly used to treat several disorders, including attention deficit, narcolepsy, and obesity. Plasmalemmal and vesicular monoamine transporters, such as the… (More)

Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.

• J. P. Hansen, Evan L. Riddle, +4 authors Annette E. Fleckenstein
• The Journal of pharmacology and experimental…
• 2002

Administration of a high-dose regimen of methamphetamine (METH) rapidly and profoundly decreases plasmalemmal and vesicular dopamine (DA) transport in the striatum, as assessed in synaptosomes and… (More)

Methylphenidate alters vesicular monoamine transport and prevents methamphetamine-induced dopaminergic deficits.

• Veronica M Sandoval, Evan L. Riddle, Glen R. Hanson, Annette E. Fleckenstein
• The Journal of pharmacology and experimental…
• 2003

It has been hypothesized that high-dose methamphetamine treatment rapidly redistributes cytoplasmic dopamine within nerve terminals, leading to intraneuronal reactive oxygen species formation and… (More)

Mechanisms of methamphetamine-induced dopaminergic neurotoxicity

• Evan L. Riddle, Annette E. Fleckenstein, Glen R. Hanson
• The AAPS Journal
• 2006

Methamphetamine (METH) is a powerful stimulant of abuse with potent addictive and neurotoxic properties. More than 2.5 decades ago, METH-induced damage to dopaminergic neurons was described. Since… (More)

Role of monoamine transporters in mediating psychostimulant effects

• Evan L. Riddle, Annette E. Fleckenstein, Glen R. Hanson
• The AAPS Journal
• 2005

Monoamine transporters such as the dopamine (DA) transporter (DAT) and the vesicular monoamine transporter-2 (VMAT-2) are critical regulators of DA disposition within the brain. Alterations in DA… (More)

Multi-tasking RGS proteins in the heart: the next therapeutic target?

• Evan L. Riddle, Raúl A. Schwartzman, Meredith Bond, Paul. A. Insel
• Circulation research
• 2005

Regulator of G-protein-signaling (RGS) proteins play a key role in the regulation of G-protein-coupled receptor (GPCR) signaling. The characteristic hallmark of RGS proteins is a conserved… (More)

Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors.

• Veronica M Sandoval, Evan L. Riddle, Glen R. Hanson, Annette E. Fleckenstein
• The Journal of neuroscience : the official…
• 2002

It is well accepted that methylphenidate (MPD) inhibits dopamine (DA) transporter function. In addition to this effect, this study demonstrates that MPD increases vesicular [3H]DA uptake and binding… (More)

A single methamphetamine administration rapidly decreases vesicular dopamine uptake.

• Jeffrey M. Brown, Evan L. Riddle, +7 authors Annette E. Fleckenstein
• The Journal of pharmacology and experimental…
• 2002

Recent studies demonstrated that vesicular dopamine (DA) uptake can be rapidly altered in synaptic vesicles purified from the striata of stimulant-treated rats. Specifically, a single administration… (More)

Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism.

• Anthony J Baucum, Kristi S Rau, Evan L. Riddle, Glen R. Hanson, Annette E. Fleckenstein
• The Journal of neuroscience : the official…
• 2004

Multiple high-dose administrations of methamphetamine (METH) both rapidly (within hours) decrease plasmalemmal dopamine (DA) uptake and cause long-term deficits in DA transporter (DAT) levels and… (More)

Therapeutic doses of amphetamine and methylphenidate selectively redistribute the vesicular monoamine transporter-2.

• Evan L. Riddle, Glen R. Hanson, Annette E. Fleckenstein
• European journal of pharmacology
• 2007

High-dose administration of psychostimulants traffics the vesicular monoamine transporter-2 (VMAT-2), as assessed by subcellular fractionation of rat striatal tissue. This study demonstrates that… (More)

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