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Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the(More)
When mutations have small effects on fitness, population size plays an important role in determining the amount and nature of deleterious genetic variation. The extent to which recent population size changes have impacted deleterious variation in humans has been a question of considerable interest and debate. An emerging consensus is that the Out-of-Africa(More)
Patients with neurologic diseases who require surgery may present the anesthetist with special challenges related to their pharmacotherapy. It is well established that such therapy may alter these patients' otherwise normal response to anesthesia. There are many classes of drugs utilized and this AANA Journal course addresses the pharmacokinetic,(More)
In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's(More)
Situations wherein patients cannot be ventilated or intubated rarely occur. When they do, however, death is imminent unless rapid and accurate actions are taken to restore adequate gas exchange. Under these circumstances, percutaneous transtracheal high-pressure jet ventilation (TTJV) through an intravenous catheter is life saving. The authors report two(More)