Evan Dorey

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Alzheimer’s disease (AD) is characterized by the accumulation and deposition of amyloid-beta (Aβ) peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration.(More)
A study is currently in progress at St Bartholomew's Hospital in which patients with B-cell lymphoma receive cyclophosphamide and total body irradiation supported by autologous bone marrow transplantation. The marrow is being treated in vitro with the monoclonal antibody anti-B1 (Coulter Immunology) and baby rabbit complement (Pel-Freez) before re-infusion(More)
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