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We carried out a Hungarian multicentre study to assess the frequency of the occurrence of warning symptoms preceding epileptic seizure. The data of 562 patients with epilepsy out of a total of 1124 were analysed on the basis of questionnaires filled in under standard conditions. About 50% of the patients experienced warning symptoms before a smaller or(More)
The present study evaluates the relation between loudness and simple reaction time (RT). Loudness matches between a narrowband noise (125 Hz wide) and a broadband noise (1500 Hz) were made at levels from near threshold to near 100 dB SPL. Over a similarly wide range of levels, RT to each of the noise bands was also measured. As reported often in previous(More)
RATIONALE Transverse tubules (TTs) couple electric surface signals to remote intracellular Ca(2+) release units (CRUs). Diffraction-limited imaging studies have proposed loss of TT components as disease mechanism in heart failure (HF). OBJECTIVES Objectives were to develop quantitative super-resolution strategies for live-cell imaging of TT membranes in(More)
Glycolysis is one of the most important metabolic pathways in heterotrophic organisms. Several genes encoding glycolytic enzymes are essential in many bacteria even under conditions when neither glycolytic nor gluconeogenic activities are required. In this study, a screening for in vivo interaction partners of glycolytic enzymes of the soil bacterium(More)
The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis. As MIF exhibits oxidoreductase activity and participates in regulating oxidative cell stress, we studied whether MIF could affect oxidative stress-induced(More)
Hearing thresholds for white-noise stimuli and temporal gap-detection thresholds in six Mongolian gerbils (Meriones unguiculatus) were determined in a GO/NOGO procedure using the method of constant stimuli. Gerbils were offspring of animals collected in the field and only bred in captivity for four generations or less. Hearing thresholds for 800 ms bursts(More)
Critical ratios (CRs) and the critical band (CB) were determined in six Mongolian gerbils (Meriones unguiculatus) using a GO/NOGO procedure and the method of constant stimuli. The test-tone frequencies were 0.5, 1, 2, 4 and 8 kHz in the CR measurements and 2 kHz in the CB measurement. Critical ratios were independent of the level of the white-noise masker.(More)
We have reported earlier that T cells found in the tumor microenvironment of head and neck cancer showed evidence of apoptosis as well as decreased expression of signaling molecules. In this prospective study, spontaneous apoptosis in tumor-infiltrating lymphocytes (TILs) and in paired circulating peripheral blood lymphocytes (PBLs) was evaluated in 28(More)
T cells with specificity for antigens derived from Wilms Tumor gene (WT1), Proteinase3 (Pr3), and mucin1 (MUC1) have been demonstrated to lyse acute myeloid leukemia (AML) blasts and multiple-myeloma (MM) cells, and strategies to enhance or induce such tumor-specific T cells by vaccination are currently being explored in multiple clinical trials. To test(More)
RATIONALE Monitoring and controlling cardiac myocyte activity with optogenetic tools offer exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac excitation from the cellular to the whole heart level. (More)