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To compare the characteristics and outcome of patients with hematological malignancies referred to the ICU with severe sepsis and septic shock who had or had not received recent intravenous chemotherapy, defined as within 3 weeks prior to ICU admission. Retrospective observational cohort study on prospectively collected data in a medical ICU of a university(More)
To compare evolution in organ dysfunction (OD) between hematologic malignancy patients with and without bacterial infection (BI) precipitating intensive care unit (ICU) admission, and to assess its impact on mortality. Retrospective analysis of prospectively collected data was performed. Sequential Organ Failure Assessment (SOFA) scores from day 1 to 5 were(More)
OBJECTIVES In patients with invasive aspergillosis (IA), fungal cultures are mostly negative. Consequently, azole resistance often remains undetected. The AsperGenius® multiplex real-time PCR assay identifies clinically relevant Aspergillus species and four resistance-associated mutations (RAMs; TR34/L98H/T289A/Y121F) in the Cyp51A gene. This multicentre(More)
BACKGROUND In January 2011, as part of an antimicrobial stewardship program the Antimicrobial Management Team (AMT) at the Ghent University Hospital initiated a multidisciplinary Infectious Diseases Team (MIT) consisting of infectious diseases physicians, clinical microbiologists, and clinical pharmacists. The aim of this study is to describe the type and(More)
Thromb Haemost 2006; 95: 896–7 The clotting factor now known as factorV (FV) was first described in 1908 (1), and a deficiency of this factor was first described by Owren as parahaemophilia in 1947 (2). FV is predominantly produced in the liver and to a lesser degree by the megakaryocytes. Circa 80% of FV circulates in the plasma while 20% is stored in(More)
BACKGROUND Malignant lactic acidosis is a potentially overlooked but life-threatening complication in patients with haematological malignancies. The aim of this study is to describe the features of six patients with malignant lactic acidosis and to discuss how its initial presentation can be differentiated from that of severe sepsis. METHODS We(More)
The accuracy and precision of an electronic cell counter equipped with a mean cell volume and packed cell volume accessory were evaluated for avian blood, and the results were compared with those of "standard" avian hematological techniques. Precision on replicate determinations with the electronic instruments was excellent and the mean results compared(More)
An acquired coagulation factor X activity deficiency was demonstrated in sheep fed Hymenoxys odorata, bitterweed plant. All coagulation tests were normal before the sheep were given the plant material. All tests involving the function of factor X, including a specific factor assay, became abnormal after the sheep were given bitterweed. Other specific(More)