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Identification and characterization of a new conjugation/type IVA secretion system (trb/tra) of Legionella pneumophila Corby localized on two mobile genomic islands.
Horizontal gene transfer probably contributes to evolution of Legionella pneumophila and its adaptation to different environments. Although horizontal gene transfer was observed in Legionella, theExpand
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First indication for a functional CRISPR/Cas system in Francisella tularensis.
Francisella tularensis is a zoonotic agent and the subspecies novicida is proposed to be a water-associated bacterium. The intracellular pathogen F. tularensis causes tularemia in humans and is knownExpand
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Regulation, integrase-dependent excision, and horizontal transfer of genomic islands in Legionella pneumophila.
Legionella pneumophila is a Gram-negative freshwater agent which multiplies in specialized nutrient-rich vacuoles of amoebae. When replicating in human alveolar macrophages, Legionella can causeExpand
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Growth-related Metabolism of the Carbon Storage Poly-3-hydroxybutyrate in Legionella pneumophila*
Legionella pneumophila, the causative agent of Legionnaires disease, has a biphasic life cycle with a switch from a replicative to a transmissive phenotype. During the replicative phase, the bacteriaExpand
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Amino Acid Uptake and Metabolism of Legionella pneumophila Hosted by Acanthamoeba castellanii*
Background: Legionella replicates within vacuoles of host cells, but less is known about its metabolism during intracellular growth. Results: Isotopologue profiles of metabolites from LegionellaExpand
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Phospholipase PlaB of Legionella pneumophila Represents a Novel Lipase Family
Legionella pneumophila possesses several phospholipases capable of host cell manipulation and lung damage. Recently, we discovered that the major cell-associated hemolytic phospholipase A (PlaB)Expand
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Phospholipase PlaB is a new virulence factor of Legionella pneumophila.
We previously identified Legionella pneumophila PlaB as the major cell-associated phospholipase A/lysophospholipase A with contact-dependent hemolytic activity. In this study, we furtherExpand
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FliA expression analysis and influence of the regulatory proteins RpoN, FleQ and FliA on virulence and in vivo fitness in Legionella pneumophila
In Legionella pneumophila, the regulation of the flagellum and the expression of virulence traits are linked. FleQ, RpoN and FliA are the major regulators of the flagellar regulon. We demonstratedExpand
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Legionella oakridgensis ATCC 33761 genome sequence and phenotypic characterization reveals its replication capacity in amoebae.
Legionella oakridgensis is able to cause Legionnaires' disease, but is less virulent compared to L. pneumophila strains and very rarely associated with human disease. L. oakridgensis is the onlyExpand
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Differential Substrate Usage and Metabolic Fluxes in Francisella tularensis Subspecies holarctica and Francisella novicida
Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease, tularemia. Whereas F. tularensis subsp. holarctica is highly pathogenic for humans, F. novicida isExpand
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