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Using resting-state functional magnetic resonance imaging, spontaneous low-frequency fluctuations in the blood oxygenation level-dependent signal were measured to investigate connectivity between key brain regions hypothesized to be differentially affected in dementia with Lewy bodies compared with Alzheimer's disease and healthy controls. These included(More)
AIMS To investigate whether subjects with dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD) have reduced entorhinal cortex (EC) volumes compared to controls and cognitively intact Parkinson's disease (PD) subjects. METHODS Volumes of the EC were measured on magnetic resonance imaging (MRI) scans of 144(More)
Functional magnetic resonance imaging recordings in the resting-state (RS) from the human brain are characterized by spontaneous low-frequency fluctuations in the blood oxygenation level dependent signal that reveal functional connectivity (FC) via their spatial synchronicity. This RS study applied network analysis to compare FC between late-life depression(More)
OBJECTIVE To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions. DESIGN Resting-state functional magnetic resonance imaging (fMRI) data were collected using a 3-Tesla MRI System. SETTING Subjects were recruited(More)
BACKGROUND Resting-state functional magnetic resonance imaging (fMRI) can be used to measure correlations in spontaneous low-frequency fluctuations in the blood oxygen level-dependent (BOLD) signal which represent functional connectivity between key brain areas. AIMS To investigate functional connectivity with regions hypothesised to be differentially(More)
The overlapping clinical symptoms of DLB and Alzheimer's disease make differentiation between the disorders difficult. This has led to the use of neuroimaging methods, for example single photon emission computed tomography (SPECT), positron emission tomography (PET), and structural and functional magnetic resonance imaging (MRI), to enhance diagnostic(More)
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