Eva Maria Zebedin-Brandl

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Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved.(More)
BACKGROUND PI3Kδ is a lipid kinase of the phosphoinositide 3-kinase class 1A family and involved in early signaling events of leukocytes regulating proliferation, differentiation and survival. Currently, several inhibitors of PI3Kδ are under investigation for the treatment of hematopoietic malignancies. In contrast to the beneficial effect of inhibiting(More)
STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences of Stat1-deficiency have been described in detail the underlying molecular functions of STAT1 in NK cells are only partially understood. Here, we describe a novel non-canonical role of STAT1 that was unmasked in NK cells expressing a Stat1-Y701F mutant. This(More)
Genetic deletion of the tyrosine kinase JAK2 or the downstream transcription factor STAT5 in liver impairs growth hormone (GH) signalling and thereby promotes fatty liver disease. Hepatic STAT5 deficiency accelerates liver tumourigenesis in presence of high GH levels. To determine whether the upstream kinase JAK2 exerts similar functions, we crossed mice(More)
Activation of Gs-coupled receptors enhances engraftment of hematopoietic stem and progenitor cells (HSPCs). We tested the hypothesis that treprostinil, a prostacyclin analog approved for the treatment of pulmonary hypertension, can be repurposed to improve hematopoietic stem cell transplantation. Murine and human HSPCs were isolated from bone marrow and(More)
In our recent article, " PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes, " 1 we set an example for the preclinical evaluation of anticancer drugs, considering both pharmacological and immunological aspects. We used the power of murine models to study the immunological consequences of the abla-tion or pharmacological blockage of(More)
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascade plays an important role in hematopoiesis. A constitutive activation of this pathway is found in a broad variety of diverse human and murine leukemias and lymphomas. Whereas STAT3 and STAT5 accelerate and initiate tumor formation, STAT1 is generally considered a(More)
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