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Familial glucocorticoid resistance is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations in the absence of stigmata of Cushing's syndrome. Our previous studies of the first reported kindred showed a two- to threefold reduction in glucocorticoid receptor-ligand binding affinity in the propositus, and a lesser(More)
The interest in minimally invasive glaucoma surgical (MIGS) procedures and devices stems from a desire to have a surgical option for the treatment of glaucoma that is associated with less serious risks and fewer complications than established procedures. Furthermore, a relatively simple and safe surgical approach may help to reduce side effects associated(More)
FLORA LUM, MD JACK T. HOLLADAY, MD, MSEE ADRIAN GLASSER, PHD SCOTT MACRAE, MD SAMUEL MASKET, MD WALTER STARK, MD EVA RORER, MD MICHELLE E. TARVER, MD, PHD DON CALOGERO, MS GENE HILMANTEL, OD TIEUVI NGUYEN, PHD MALVINA EYDELMAN, MD The American Academy of Ophthalmology, San Francisco, California; Clinical Professor, Department of Ophthalmology, Baylor(More)
OBJECTIVES To assess material properties that affect preservative uptake by silicone hydrogel lenses. METHODS We evaluated the water content (using differential scanning calorimetry), effective pore size (using probe penetration), and preservative uptake (using high-performance liquid chromatography with spectrophotometric detection) of silicone and(More)
When evaluating how a medical product affects vision, it is important to assess how that product affects the ability to function in real life, not only the ability to read letters on a vision chart. Nevertheless, the measurement of visual acuity with a vision chart remains the primary test of the effects of medical products on vision. Here, we review(More)
OBJECTIVE To compare participants' responses to Web-based and paper-and-pencil versions of an ophthalmic, patient-reported outcome (PRO) questionnaire. DESIGN Questionnaire development. PARTICIPANTS Matched subjects with ocular surface disease (OSD) (n = 68) and without OSD (controls, n = 50). METHODS Subjects completed a standard, paper-and-pencil(More)
PURPOSE MRL/MpJ-+/+ (MRL/+) and MRL/MpJ-lpr/lpr (MRL/lpr) mice show spontaneous development of a T-cell-driven lacrimal gland inflammation that is a model for Sjögren syndrome. The lacrimal gland lesions in these mice were evaluated by quantitative RT-PCR for selected cytokine mRNA for the relative contributions of T-helper (Th)1 versus Th2 immune responses(More)