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3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells

• Nicolas Girard, Céline Bazille, +4 authors Catherine Baugé
• PloS one
• 2014

OBJECTIVE Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate therapeutic target in some tumors. Indeed, a high expression of EZH2… (More)

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

• Catherine Baugé, Nicolas Girard, Eva Lhuissier, Céline Bazille, Karim Boumédiene
• Aging and disease
• 2014

Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor… (More)

Histone methylases as novel drug targets: developing inhibitors of EZH2.

• Catherine Baugé, Céline Bazille, Nicolas Girard, Eva Lhuissier, Karim Boumédiene
• Future medicinal chemistry
• 2014

Post-translational modifications of histones (so-called epigenetic modifications) play a major role in transcriptional control and normal development, and are tightly regulated. Disruption of their… (More)

Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

• Eva Lhuissier, Céline Bazille, +5 authors Catherine Baugé
• BMC Cancer
• 2017

Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from… (More)

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice

• Eva Lhuissier, Juliette Aury-Landas, +5 authors Catherine Baugé
• Oncotarget
• 2018

Cancer patients display cognitive impairment due, at least partly, to the treatments. Additionally, chemotherapeutic treatments can lead to organ injury, limiting their use, and are likely to have… (More)

Anti-inflammatory effects of an injectable copolymer of fatty acids (Ara 3000 beta®) in joint diseases

• Catherine Baugé, Eva Lhuissier, Nicolas Girard, Céline Quesnelle, Gérard Ewert, Karim Boumédiene
• Journal of Inflammation
• 2015

In inflammatory joint disease, such as osteoarthritis or arthritis, there is an increased level of pro-inflammatory cytokines, such as interleukin-1β. These cytokines stimulate the expression and… (More)

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