Eva Hartlieb

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To define the extent to which impulse blockade interferes with the morphological changes of regenerating retinal axons during their growth through the tectum, axons were deprived of activity by repeated intraocular injections of TTX. At intervals between 24 and 189 days after optic nerve section (ONS), a defined group of TTX-silenced axons and of axons with(More)
Following optic nerve section (ONS) in goldfish, the right eye was repeatedly injected with tetrodotoxin (TTX) and the left eye with Ringer solution. At various survival periods after ONS, horseradish peroxidase (HRP) was applied to small groups of axons in dorsal or ventral retina in both eyes. Counts of labeled regenerating retinal axons show that 43 +/-(More)
Moth behaviour is to a great extent guided by olfactory stimuli with different relevance. We investigated whether olfactory learning of odours is influenced by the behavioural significance of the odorant. In proboscis extension conditioning experiments species-specific sex pheromones, which normally elicit an innate behaviour in males, and a flower odour(More)
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed. However, the(More)
Desmosomes provide strong intercellular cohesion essential for the integrity of cells and tissues exposed to continuous mechanical stress. For desmosome assembly, constitutively synthesized desmosomal cadherins translocate to the cell–cell border, cluster and mature in the presence of Ca2+ to stable cell contacts. As adherens junctions precede the formation(More)
Purpose The autoimmune blistering skin disease pemphigus vulgaris (PV) is caused by autoantibodies against desmosomal adhesion molecules. Patients may suffer conjunctival involvement, yet the underlying mechanisms are largely unclear. We characterized human and murine conjunctiva with respect to the PV autoantigens, and evaluated the effects and mechanisms(More)
AIMS We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. METHODS AND RESULTS We studied intercalated discs of(More)
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