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The Pediatric Quality of Life InventoryTM (PedsQLTM) is a relatively new instrument developed in the US to assess health-related quality of life (HRQL) in healthy and ill children and adolescents. It is quick and easy to use, suitable for assessment by children and parents and based on a modular approach with a generic measure addressing all general domains(More)
The purpose of the present study was the assessment of health-related quality of life in adult long-term survivors of childhood cancer and the detection of possible treatment- and cancer-related late effects. The relation of objective medical data and subjective appraisal was also examined by combining the doctor’s and the patient’s views of the perceived(More)
Steady progress in developing effective treatments for childhood cancer and other severe pediatric diseases has established the need to consider the nature and frequency of late physical and psychological effects. The Health Utilities Index Mark 2 and Mark 3 (HUI2/3) systems were developed by Feeny, Furlong, Torrance et al. in Canada. These systems are(More)
BACKGROUND Studies on gastrointestinal stromal tumours (GIST) in the paediatric population are limited to case reports or small case series. PATIENTS AND METHODS We conducted a retrospective study to describe the long-term outcome of children and adolescents with GIST registered in the database of the Cooperative Weichteilsarkom Studiengruppe (CWS). (More)
PURPOSE OF REVIEW In the past 20 years, several papers have been published concerning healthcare transition from pediatric after-care to long-term follow-up in adult health service for childhood cancer survivors. Initially, the papers were optimistic and included guidelines and models of care. However, after this optimistic beginning, more recent research(More)
  • Eva Frey
  • Histoire des sciences medicales
  • 1982
B o t h the Un i t ed S t a t e s a n d F r a n c e h a v e developed sa f egua rds aga ins t t h e d i s t r i b u t i o n of u n r e g u l a t e d m e d i c a l r e m e d i e s . The p rocess by w h i c h these safe­ g u a r d s have been pu t in to effect h a s been very di f ferent in t h e t w o coun t r i e s , a n d ref lects a difference in a t t i(More)
To describe the course of hepatitis C in a cohort of 105 survivors after childhood cancer. Data on chemo/radiotherapy, clinical status, serial alanine aminotransferase (ALT) evaluation, and virological parameters after the end of treatment were collected for each patient. Liver biopsies, when performed, were centrally evaluated by a pathologist. All(More)
Die Schilddrüsenfunktionsstörungen vor und nach einer Stammzelltransplantation (SZT) bei Kindern und Jugendlichen wurden untersucht und erfasst. Im Rahmen eines komplexen, longitudinal ausgerichteten und multizentrisch angelegten deutsch-österreichischen Nachsorgeprogramms nach Stammzelltransplantation wurden 416 Patienten zwischen 1996 und 2002 erfasst. Im(More)
Objective: To evaluate late effects concerning growth and endocrine function in children and adolescents after stem cell transplantation (SCT). Patients and Methods: 318 patients treated with SCT from 1996 to 1999 were investigated for late effects. The underlying diseases were ALL 21%, AML 13%, CML 7%, MDS 8%, lymphoma 4%, SAA 8%, NB 11%, solid tumours 15%(More)
Survival after childhood cancer has improved substantially over recent decades. Although cancer in childhood is rare increasingly effective treatments have led to a growing number of long-term survivors. It is estimated that there are between 300,000 and 500,000 childhood cancer survivors in Europe. Such good survival prospects raise important questions(More)