Eva-Christine Weiss

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BACKGROUND Biomarkers predictive of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) of breast cancer are urgently needed. METHODS Using a training/validation approach for detection of predictive biomarkers in HER2-negative breast cancer, pre-therapeutic core biopsies from four independent cohorts were investigated: Gene array data(More)
A purification process for the monoclonal anti-CD4 antibody MAX.16H5 was developed on an analytical scale using (NH4)2SO4 precipitation, anion-exchange chromatography on MonoQ or Q-Sepharose, hydrophobic interaction chromatography on phenyl-Sepharose and gel filtration chromatography on Superdex 200. The purification schedule was scaled up and gram amounts(More)
Blood samples were obtained by the family physician and immediately sent to the laboratory for testing. All subjects investigated gave full written and informed consent for genetic testing in accordance with the Austrian Gene Technology Act. EDTA whole blood was used for the genetic testing of factor V Leiden (F5 R506Q), employing a customized 5'-nuclease(More)
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